Back-to-BACs in Huntington's disease modeling

Hyeseung Lee; Myriam Heiman

doi:10.1016/j.neuron.2022.02.022

Back-to-BACs in Huntington's disease modeling

Neuron. 2022 Apr 6;110(7):1087-1089. doi: 10.1016/j.neuron.2022.02.022.

Authors

Hyeseung Lee¹, Myriam Heiman²

Affiliations

¹ Picower Institute for Learning and Memory, Cambridge, MA, USA.
² Picower Institute for Learning and Memory, Cambridge, MA, USA; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA, USA. Electronic address: mheiman@mit.edu.

PMID: 35390285
DOI: 10.1016/j.neuron.2022.02.022

Abstract

In this issue of Neuron, Gu et al. (2022) describe a new BAC mouse model that faithfully recapitulates various aspects of Huntington's disease pathobiology and reveals important insights into the relative toxicities of mHTT-derived products.

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MeSH terms

Animals
Disease Models, Animal
Huntingtin Protein / genetics
Huntington Disease* / genetics
Mice
Neurons / physiology

Substances

Huntingtin Protein