Xylarkarynone A and B:Two Bioactive Eremophilane Sesquiterpenes from Xylaria sp. HHY-2

Li Zhu; Sheng-Qi Zhang; Yi-Nong Wang; Jia-Xin Wang; Cheng-Yao Wang; Lan Cai; Zhao-Fei Wen; Liang Deng; Le Cai

doi:10.1002/cbdv.202400900

Xylarkarynone A and B:Two Bioactive Eremophilane Sesquiterpenes from Xylaria sp. HHY-2

Chem Biodivers. 2024 May 7:e202400900. doi: 10.1002/cbdv.202400900. Online ahead of print.

Authors

Li Zhu¹, Sheng-Qi Zhang¹, Yi-Nong Wang¹, Jia-Xin Wang¹, Cheng-Yao Wang¹, Lan Cai¹, Zhao-Fei Wen¹, Liang Deng², Le Cai³

Affiliations

¹ Yunnan University, School of Chemical Science and Technology, No. 2 North Cuihu Rd, kunming, CHINA.
² Kunming Medical University, college of pharmacy, yuhua street, kunming, CHINA.
³ Yunnan University, Key Laboratory of Functional Molecules Analysis and Biotransformation, Yunnan Provincial Department of Education,, No. 2 North Cuihu Rd, 650091, Kunming, CHINA.

PMID: 38713316
DOI: 10.1002/cbdv.202400900

Abstract

A new compound xylarkarynone A (1), a first reported natural product compound xylarkarynone B (2) and eight known compounds (3-10) were isolated from Xylaria sp. HHY-2. Their structures were elucidated by spectroscopic methods, DP4+ probability analyses and electronic circular dichroism (ECD) calculations. The bioactivities of isolated compounds were assayed. Compound 1 exhibited obvious activity against A549 cells with an IC50 value of 6.12 ± 0.28 µM. Additionally, compound 1 showed moderate antifungal activities against Plectosphaerella cucumerina and Aspergillus niger with minimum inhibitory concentrations (MICs) of both 16 µg/mL, which was at the same grade with positive control nystatin. Most compounds exhibited varying degrees of inhibitory activity against P. cucumerina, indicating that Xylaria sp. has potential as inhibitors against P. cucumerina.

Keywords: Biological activity; Eremophilane-type Sesquiterpene; Illigera rhodantha (Hernandiaceae); Natural products; Xylaria sp.